Loctite Corporation began in the Trinity College basement laboratory of Dr. Vernon Krieble of Hartford, Connecticut in 1953. This entrepreneurial chemistry professor developed a cure inhibition system for a unique bonding resin that hardened in the absence of air, an anaerobic sealant.

Loctite made its official public debut at a press conference at the University Club in New York on July 26, 1956. The promise of solving the age-old problem of loose nuts and bolts in machines and appliances, a problem customers had long ago accepted as unsolvable, led to an incredible flow of inquiries. In the 1960s, the Cyanoacrylate or CA (“Superglue”), a very fast one-part, room-temperature industrial adhesive, had been developed under the Loctite® brand.  The development of further generations of Loctite anaerobics and cyanoacrylate technology and products soon followed.

Throughout its history, Loctite has continuously created markets by discovering opportunities. From its founding, based on a product that solved an "unsolvable" problem, Loctite has achieved success through innovation.  In 1997 Loctite was acquired by Henkel and remains a primary brand to this day.